Name of Medicine
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چکیده
The active ingredient of METALYSE (tenecteplase) is a recombinant fibrin-specific plasminogen activator that is derived from native t-PA by modification at three sites of the protein structure. It binds to the fibrin component of the thrombus (blood clot) and selectively converts thrombus-bound plasminogen to plasmin, which degrades the fibrin matrix of the thrombus. Tenecteplase has a higher fibrin specificity and greater resistance to inactivation by its endogenous inhibitor (PAI-1) compared to native t-PA.
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